Scientists grow human brain cells in mice to study disease.

Scientists transplanted human brain cells into the brains of baby mice, where the cells grew and formed connections. In an effort to better study human brain development and the diseases that affect this most complex organ, this has made us what we are today, but it didn’t last long. shrouded in mystery. “Many disorders, such as autism and schizophrenia, may be unique to humans.” But “the human brain was definitely not accessible,” said Dr. Sergiu Pasca, lead author of the study published Wednesday in the journal Nature.Approaches. Anything unrelated to removing tissue from the human brain is “a promising avenue in attempts to address these conditions.” The study builds on the team’s previous work to create brain “organoids,” tiny structures that resemble human organs. Others such as the liver, kidneys, prostate, or major parts thereof. To make brain organoids, scientists at Stanford University transformed human skin cells into stem cells and then turned them into different types of brain cells. Those cells then multiply to form organoids that resemble the cerebral cortex, the outermost layer of the human brain. These organoids play important roles in things like memory, thinking, learning, reasoning, and emotion. Scientists implanted these organoids into young mice that were two to three days old. Brain connections are still being formed. The organoids grew and eventually took up a third of the brain hemispheres of the transplanted mice. Neurons in organoids have formed working connections with circuits in the brain. Human neurons have previously been transplanted into rodents, but typically into adult animals, typically mice. “This is the first time these organoids have been inserted into the brains of early mice,” said Pasca, a professor of psychiatry at Stanford University School of Medicine. .” To investigate the practical use of this approach, scientists implanted organoids on both sides of the rat brain.Heart problems and autism spectrum disorders.After 5-6 months, they saw the effects of the disease related to neuronal activity. There was a difference in activity, and neurons in people with Timothy’s syndrome were much smaller and didn’t expand enough to collect input from nearby neurons. of the experiment can be conducted and potentially learn something new about how these conditions affect the brain: Flora Baccarino of Yale University, who has previously grown chunks containing the cerebral cortex made from DNA from people with autism. Flora Vaccarino) said this research advances the field in the future. Vaccarino, who was not involved in the study, said: These experiments on animals raise ethical issues. For example, Pasca said that he and his team “We are aware of the well-being of rats and whether rats are behaving normally with the organoids inside. But Pasca doesn’t think this should be tried in primates. Ethicists also say that in the future, brain organoids may be like human consciousness.” Curious about the feasibility of achieving that, which experts say is almost impossible at the moment, for example, researchers at the ETH Zurich in Switzerland published in Nature earlier this month to grow brain-like tissue from stem cells in a lab. Then he published a study describing how to map cell types in different brain regions and genes that control development. Some are using these constructs to study autism. It could also be used to test new treatments for neuropsychiatric disorders, the number one cause, he said, making it very difficult for such studies to reach the human brain. Because it is difficult, he said, it will help scientists make progress that has hitherto been very difficult. Medicine in terms of treatment.”___The AP Health and Sciences Department is supported by the Howard Hughes Medical Research Institute’s Science Education Department. AP assumes full responsibility for all content.
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