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Warning: Popular vitamin supplements cause cancer risk and brain metastasis

A new study finds that nicotinamide riboside, a popular dietary supplement, may increase the risk of serious diseases, including cancer. Researchers at the University of Missouri discovered it while using bioluminescent imaging technology to study how nicotinamide riboside supplementation works in the body. Riboside (NR), a form of commercial dietary supplement vitamin B3 such as nicotinamide, has been associated with benefits related to cardiovascular, metabolic, and neurological health in previous studies. However, a new study from the University of Missouri (MU) suggests that NR may actually increase your risk of serious diseases, including cancer. Supplements containing nicotinamide riboside are often used as NAD+ boosters for increased energy, anti-aging/longevity/healthy aging, improved cellular energy metabolism and recovery, increased vitality and improved heart health. Scientists have found that high levels of NR may increase someone’s risk of developing triple-negative breast cancer, as well as cancer. The international team of researchers was led by Elena Goun, associate professor of chemistry at MU and the corresponding author of the study. When the cancer reaches the brain, she said, the consequences are fatal because there is currently no viable treatment. [vitamins and supplements] Because they automatically assume that vitamins and supplements only have positive health benefits, but little is known about how they actually work,” Goun said. “This lack of knowledge has led us to study the fundamental questions of how vitamins and supplements work in the body.” After his 59-year-old father died just three months after being diagnosed with colon cancer, Goun was moved by his father’s death to pursue a better scientific understanding of cancer metabolism, the energy that cancer spreads through the body. NR is a supplement known to help increase cellular energy levels, and cancer cells consume that energy as their metabolism increases, so Goun wanted to investigate the role of NR in the development and spread of cancer. Elena Goun. Credits: University of Missouri Goun said, “Our work is particularly important given its wide commercial availability and the large number of ongoing human clinical trials in which NR is used to alleviate the side effects of cancer treatment in patients.” Researchers have used this technology to: Compare and investigate how many NR levels are present in cancer cells, T cells and healthy tissues. “Although NR is already widely used in people and is being investigated in many ongoing clinical trials for further applications, much of the way NR works is a black box — it is not understood,” Goun said. “So we came up with this novel imaging technique based on ultra-sensitive bioluminescence imaging that can quantify NR levels in real time in a non-invasive manner. The presence of NR is indicated with the light, the brighter the light, the more NR present.” In her findings, Goun stressed the importance of carefully examining the potential side effects of supplements like NR. People who may have different types of health conditions. Going forward, Goun hopes to provide information that can lead to the development of specific inhibitors, which can help make cancer treatments such as chemotherapy more effective in treating cancer. The key to this approach, Goun said, is to look at it from the perspective of personalized medicine. “Not all cancers are the same for everyone,” she said. Especially in terms of metabolic signs,” Goun said. “Often cancer can also alter metabolism before and after chemotherapy,” she said. References: Tamara Maric, Arkadiy Bazhin, Pavlo Khodakivskyi, Georgy Mikhaylov, Ekaterina Solodnikova, Aleksey Yevtodiyenko, Greta Maria Paola Giordano Attianese, George Coukos, Melita Irving, Bioelectronics Joffraud, Carles Cantó, and Elena Goun, 29 October 2022. 0.2.6, Bioelectronics. Other authors of this study are Arkadiy Bazhin, Pavlo Khodakivskyi, Ekaterina Solodnikova and Aleksey Yevtodiyenko from MU. Tamara Maric of the Swiss Federal Institute of Technology; Greta Maria Paola Giordano Attianese, George Coukos, Melita Irving, Ludwig Cancer Research Institute, Switzerland Magali Joffraud and Carles Cantó, Nestlé Institute of Health Sciences, Switzerland. Bazhin, Khodakivskyi, Mikhaylov, Solodnikova, Yevtodiyenko and Goun are also affiliated with the Swiss Federal Institute of Technology. Mikhaylov, Yevtodiyenko and Goun are also affiliated with SwissLumix SARL in Switzerland. Funding was provided by grants from the European Research Council (ERC-2019-COG, 866338) and the Swiss National Foundation (51NF40_185898) and with support from NCCR Chemical Biology. .
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